The creator of these comics is a Christian, with the message of them being a Christian message/allegory.
The message here is that if you disconnect yourself from God and try to live independent from God, you lose your purpose and/or are helpless to fulfill your "true purpose" (which, to a Christian, "true purpose" = serving/following God).
That said: I'd strongly suggest that people stop posting these comics and giving this guy attention. They're meant for Christians and are not really relevant to people outside of that.
EDIT: I made a (regrettable) visit to the website to satisfy my curiosity and found the title & description:
Absolute Freedom – God (in control of all things) gives us freedom to choose what to do, but we don't get to choose the outcome.
What's missing is that you haven't drank the Kool aid, if I had to guess. They lean entirely on you being a believer (and usually a devout one) for any of their material to land, whether it's comedy or drama or music or whatever.
I also feel they think too highly of themselves, and aren't willing to laugh at themselves. A lot of humour relies on being willing to laugh at yourself, your mistakes, and your beliefs, and Christian fundies aren't willing to do that.
The puppeteer can make you cut your own ties at any time and leave you in a ditch 'cause you were kept a dependent weakling. The author is accidentally promoting self reliance, because that interpretation is not allowed to him or his public. Stupid comics.