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A consistent system settings app that actually handles all configs without requireing manual editing of config files.
Which DE? With KDE I don't think I've ever had to edit a config file. I do recall that being an issue with Gnome; it's been years since I've used it though.
XFCE is really bad with this. KDE is much better, but still when setting up something a bit more complicated, you are quickly back to reading man pages. And man pages really aren't great.
On KDE, if you want NumLock to start on at the login screen, you need to edit a file.
Also, to remap mouse side buttons, you need to either mess with a config file or install something like Input Remapper.
Neither of these things are true, if you're using Wayland for both sddm and the session