The world record for 2.0+ standard currently sits at 2h56m14s. Glitchless has no 2.0+ submitted still, but the pre-2.0 record is 3h12m10s. So it should be plenty doable if someone just wants to run through the main game and some side stuff.
Now 100% while it's free would probably be interesting without the knowledge of glitches that would speed things up.
I spent 112 hours to complete the game 100%, that was my first play through so I listened to all the dialogue and took things slowly. I think it might be possible within 48 hours
Yeah if you don't bother with all the dialog it shortens the time a lot. Even just being able to read subtitles faster than they speak and skipping lines as you do cuts down time.
The speedrun scene looks fairly dead, the newest submission looks to be from 11 months ago, and only Phantom Liberty. This may breathe new life into it. Other games have seen a bunch of new runs during free trials.