AFAIK, there is no reasonable desktop CPU that is not either very underpowered compared to alternatives or a Mac. Wouldn't framework need to work with a partner to design a whole desktop class of CPU like apple did?
Then after that hurdle, then you are limited to a much smaller selection of apps due to architecture.
I guess we'll see how Qualcomm's chips turn out. Right now we only have synthetic benchmark leaks, which look good, but ARM CPUs often look good in synthetic workloads only to fall short in real ones, particularly when compared against an X86 system.
The rumour mill is also saying that AMD will be making ARM CPUs in a while - allegedly, they formed an ARM design team in order to try to get the Nintendo Switch 2 contract, but Nintendo stuck with Nvidia because they don't want any potential issues with Switch 1 backwards compatibility.
AMD then kept this design team and will be making laptop SoCs now that ARM on Windows is starting to mature and Qualcomm's exclusivity deal (yes, they had an exclusivity deal. That's why all current Windows ARM machines are Qualcomm) is ending.
Not actually the first time AMD has worked on ARM. They made K12, but it was scrapped in favour of Zen when it was clear AMD only had the resources to work on one architecture.