Realistically, immutability wouldn't have made a difference. Definition updates like this are generally not considered part of the provisioned OS (since they change somewhere around hourly) and would go into /var or the like, which is mutable persistent state on nearly every otherwise immutable OS. Snapshots like Timeshift are more likely to help.
Anything that’s updated with the OS can be rolled back. Now Windows is Windows so Crowdstrike handles things it’s own way. But I bet if Canonical or RedHat were to make their own versions of Crowdstrike, they would push updates through the o regular packages repo, allowing it to be rolled back.
It's a huge reason why I use BTRFS snapshots. I'm a bit more lax about what gets snapshotted on my desktop, but on a server, everything should live in a snapshot. If an update goes bad, revert to the last snapshot (and snapshots are cheap, so run one with every change and delete older ones).