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Best: depends on needs and usecases. Obviously, the majority will name the distro they use here, because if they would think another distro is better they would switch.
Worst: either Pop_OS (the most pointless, with the killer feature of "nvidia blob out of the box", saving literally one command after installation), or Fedora (RedHat + too unstable + and too much RedHat new experimental shit being tested). Sorry for those who like those distros, but that's my opinion.
I've been looking at Pop! OS recently because I want to start using Linux again but I feel like it's a standard Ubuntu-based distro with a few things preinstalled. How's that different to any other distro with GNOME UI after I install the same packages?
Everyone has their own opinions. I tried a ton of different distros, the tiling windows manager in Pop! OS was the feature that I couldn't move away from once I adjusted to it. The OS just gets out of the way and lets me work, and my efficiency is up.