You can play Doom using gut bacteria, but the framerate is atrocious

It’s worth noting that Ramlan herself points out that “running” Doom using the cells would be an enormous undertaking due to their extremely limited ability. What she did manage to successfully do, however, is use the wall of cells as a display for Doom by rendering gameplay using the illuminated E. coli.

It's interesting but it's not running doom but serve as a display.