If a person is taking medication for depression, and goes out to drink the same night, can they get a negative reaction?

This is for a novel im writing. For a point in the story, a girl is taking meds and is convinced by friends to go and drink and she has a negative reaction and wakes go the next day remembering nothing.

But Im not a medic so I dont know how realistic this is. What would happen if a person takes meds like anti depresants, and afterna few hours drink alcohol? What would happen to them?