When I managed a pizza place, people would ask if the driver could bring change for $100. I'd tell them if they wanted to leave a $50 tip, the driver can give them his $20.
One time a dude was really blazed and handed a driver a $50 bill instead of a 5, but that's the only time I can think of outside especially large orders.
Also, all we're expected to do in that situation is remake the pizza and deliver it. As long as no one is being hurt, I wouldn't mind someone just holding me up for the pizza, I guess.