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The comic subverts our expectations when we expect that "it's complicated" is just an easy way to brush off the question only to find out that the answer is in fact, complicated. The juxtaposition of a normal social situation with the absurdity of the mouse hospital pizza parlor serves to further build the humour in this comic.
So glad I paid $300 to take that humour theory class in college.
$300.00 well spent!
Yep. We find things humorous if they're a benign violation of our expectations. That's also why some folks judge others for their taste in humor; either they see something as not benign (e.g., people getting injured) or not a violation of expectations (e.g.,"stupid," or wholly predictable).
Send me your billables, this is awesome