Is it possible to have a long-term/"forever" modded minecraft world?

I'm always fascinated with the idea of a forever world, but I got always bored out with the vanilla options. Since my friend introcued me to Create, I have instantly became obsessed with a forever modded minecraft world.

If it's sorta possible, what type of mods should I avoid to include in a forever Create and Ad Astra modpack, aside from possibly inactive mods? Is Biomes O Plenty a no-go as an example since it's a world gen mod?

EDIT: By long-term I mean playing a world through release updates.