In a comic, when two people have their mouths open at the same time and there are no lines/speech bubbles, it's hard to tell who's saying the dialogue. That is all.
Estrogen therapy for transfems takes a while to have noticeable effects.
Two of the earliest effects for people are softer skin and growing areolas. I read a blog yesterday where the author said one of the first effects she noticed was her nipples growing to look like cis women's.