I am expecting a lot of Disco Elysium, here...and nothing wrong with that!
A video gaming student organization I was once part of actually had a vote on their favorite sayings. The winner was the evergreen "Perhaps the same said could be said of all religions..." from Castlevania: Symphony of the Night! https://www.youtube.com/watch?v=OMTizJemHO8
My personal favorite? It's hard to say...but hey, that's what the scientist in Half-Life can comment, word to word! So maybe I'll put forward, said by the aforementioned: "My god, what are doing!?"
With this character's death, the thread of prophecy is severed. Restore a saved game to restore the weave of fate, or persist in the doomed world you have created.
I think about this one every now and then. It's a bummer that they've doubled down on the immortal quest NPCs time and time again.