I am expecting a lot of Disco Elysium, here...and nothing wrong with that!
A video gaming student organization I was once part of actually had a vote on their favorite sayings. The winner was the evergreen "Perhaps the same said could be said of all religions..." from Castlevania: Symphony of the Night! https://www.youtube.com/watch?v=OMTizJemHO8
My personal favorite? It's hard to say...but hey, that's what the scientist in Half-Life can comment, word to word! So maybe I'll put forward, said by the aforementioned: "My god, what are doing!?"
Darkest Dungeon 1 & 2 are full of gems.
"Slowly, gently. This is how a life it taken."
"Many heroes fall in the face of chaos. But not this one; not today."
"At one point he was mourned. Now he's just... gone."