I just made the switch and Steam with Proton has been really smooth, they've made a lot of progress to make it easy since the Steam Deck has come out. I don't play any online competitive games that use anti-cheat though.
I just recently tried a game running with proton (which i understand is wine with extras). I was really impressed cause i download it and it was just running. Maybe i got lucky or it was just the game (valheim).
My only big trouble with all of this is the hardware management, not having access to software like adrenaline gives me a bad feeling. I ran the game steadily with the GPU at around 60°C, but certain situations, and specially the "start up" produced peaks of 90°C in really small time windows. Thats holding me for now.
As I understand, valheim has a linux native version but i wamted to try proton after all.
I was able to get an indie title to work but it wasn't the two games I was playing at the time. Guardians of the galaxy and RE4. I'm currently on FFXIV which has a silver or gold on the "does it work" site I forget what it's called. But not having adrenaline is kind of a bummer. I use that too. The frame generation is a great feature.
Using wine can be a bit troublesome especially if you're new to linux. For example wine doesn't come with dxvk which is basically mandatory for playing games nowadays.
Most people use another program to deal with wine, like lutris, bottles, or steam with the built in proton.
Lutris is what i should have said, that's what I was using, but I think what made me think wine was the dependencies of sorts in the settings of lutris. I really wish I could get it down because I liked PopOS a lot.