Most those safes are laughably bad at security. Especially when the hotel can reset the pin incase a guest forgets and the instructions on how are on the internet.
I mean, what valuables are you leaving in your hotel room? The only thing in there for me is usually my clothes, and while they may be kinda nice, they're really far from resell-them-at-a-profit-nice.
Deviant Ollam has done a couple of videos about hotel security. One of them--one that I can't find right now--used a wedge that had an adjustment screw, so that even if the lock was cracked, you needed a battering ram to open the door. OTOH, you could only use it while you were in the room, so it's not any good at protecting valuable objects while you're not in the room.
If you're being personally targeted by someone with any real level of skill, or an organization with resources, most security measures that you have available to you as an individual of modest means are unlikely to help significantly. In general, locks are there to keep honest people honest, and that's about it.
The only real solution here is to allow guests to bring their own locks. So there could be one lock provided by the hotel and accessible by the maids, and a second lock with a deadbolt that you could provide your own core for.
If you want your room cleaned, leave your lock unlocked.
If you want to do that, you put down a deposit (like $100-200 for a locksmith to come) to get the master key for changing the lock, and you get the deposit back at checkout once they prove you've removed it (could be a digital check). That way the hotel is never out anything aside from the inconvenience of calling a locksmith, and guests get the option of better security and privacy.