What do you use for key rebinding in games?

I've just switched over from Windows to Linux for my daily driver in the last few weeks, and after the initial learning curves everything seems pretty solid. The only thing I really, really need for some games is the ability to rebind keys that the game itself doesn't allow. Examples would be Orcs Must Die 1 (no rebinding at all) or Dyson Sphere Program (my current issue) which has the E key hardcoded. I use ESDF for movement so I have to rebind pretty much every game.

I had tons of AutoHotKey scripts in Windows but I haven't found anything comparable in Linux. What do you guys use? I've looked at AHK_X11 but every post I saw about it says it doesn't work. I tried Autokey but found it clunky and it didn't work properly in-game (micro-pauses between key repeats).

Really just looking for something that can easily rebind a few keys just for a game session. I know I'm going to have to learn xdotool and python for mouse stuff, that's on my to-do list. :) But the vast majority of my games just need rebinding a few keys. Throw your wisdom at me. Thanks!