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Did a top NIH official manipulate Alzheimer's and Parkinson’s studies for decades? (alt: Eliezer Masliah's papers under investigation)
web.archive.org Did a top NIH official manipulate Alzheimer's and Parkinson’s studies for decades?

Agency announces research misconduct finding for neuroscientist Eliezer Masliah as scores of his papers fall under suspicion

A Science News report about Dr. Eliezer Masliah (who held a highly important role at the National Institute of Aging), a 300-page dossier composed of misconducts at his lab, as well as followups... Featuring everyone's favorite research integrity sleuths (Elizabeth Bik, Mu Yang, "Cheshire", ...) and more.

Post URL points to archive.org due to soft paywall on Science News. Here's the original link

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To Americans: How far apart is everything in the US?
  • Oh boy. I used to live in Houston, TX, a city notorious for being car-dependent...

    I will present three sets of numbers. First is where I first moved to in Houston, in a supposedly highly coveted, super walkable area home to mostly medical students... Second is the place I lived before I moved out (and I used to boast to people how accessible the place was, by US standards). Third is in Chicago, close to city center ("The Loop").

    And FYI I only lived in places that would be considered to be within the city, so these might be as small as they can get...

    • To the nearest convenience store: 900m | 750m | 170m
    • To the nearest chain supermarket: 700m(used to be 4.2km) | 450m | 220m
    • To the bus stop: 160m(never seen anyone there though) | 350m | 71m
    • To the nearest park: 950m | 1.5km | 1.6km
    • To the nearest big supermarket: 700m(used to be 4.2km) | 450m | 450m
    • To the nearest library: 1.2km | 450m | 1.0km
    • To the nearest train station: 7.0km | 3.8km | 2.5km

    Fun story about the first location! Everything seems so walkable on paper (close to park, close to highway), until you realize that there was no fucking supermarket anywhere within walking distance... H-E-B only opened a store closeby after I moved there. However, even the super-close grocery store is across the highway and I almost never see any sane people walk there so... For parks I am only counting ones that are good enough to be tourist-worthy, otherwise the latter two locations have pretty easy access to lots of green space

    And if you are asking about public transit that are not bus/train: respective distances are 1.4km | 1.0km | 280m. The last number in this series is basically how I chose where to live...

  • What is the hardest video game(s) in your opinion, why, and what other games are you comparing against to make this conclusion?
  • I've actually been waiting for anyone to mention any rhythm games at all. I think rhythm games in general tend to have low skill floor, but insanely high skill ceilings (Freedom Dive, some Hatsune Miku songs, ...), which make them an interesting case on the difficulty scale... Some rhythm games have unintuitive control too (OSU being a prime example with the mouse control, also Taiko series) which makes them even more difficult

    Side note: I find it hilarious that the original game which OSU was based on was actually just a "tap a tablet" game though (Ouendan series, use stylus to click bottom screen of NDS)... also some JP arcades stock Reflec Beat and crossbeats Rev, Round1 has an exclusive game Tetote Connect, which are all "tap a button on the screen" games but you touch the screen with your hands instead

    I agree, even the hardest non-rhythm games I seem to be able to get accustomed to in 50~100 hours, but not some of these monstrosities

  • What music do you use for concentration?
  • One of:

    1. none,
    2. lofi, or
    3. wild speedcore music beyond most people's imagination

    Although I think options 2 and 3 are more helpful for helping me getting back from being distracted rather than concentration itself...

  • Octopuses and fish caught on camera hunting as a team (ft. octopus punching fish)
    www.nature.com Octopuses and fish caught on camera hunting as a team

    Although typically viewed as solitary animals, octopuses sometimes work with fish to entrap prey.

    Octopuses and fish caught on camera hunting as a team

    "Octopuses normally hunt alone, but footage captured by divers has revealed that they can collaborate with fish to find their next meal. The videos, described today in Nature Ecology & Evolution (citation 1), show that the different species even adopt specific roles to maximize the success of joint hunting expeditions."

    Associated research article (open access): Sampaio E et al. Multidimensional social influence drives leadership and composition-dependent success in octopus–fish hunting groups. Nature Ecology & Evolution (2024). https://doi.org/10.1038/s41559-024-02525-2

    Same news that was independently reported by Science News (might need membership): https://www.science.org/content/article/some-octopuses-treat-fish-hunting-buddies

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    What is the hardest video game(s) in your opinion, why, and what other games are you comparing against to make this conclusion?
  • I'm glad you mentioned this! I completely agree... Which is kinda why I was asking about this in the first place. I was curious what others consider as objectively "difficult" for them, and I got my answer: my sense of "difficult" is very different from that of most Lemmy users...

    fake difficulty

    IMO I felt a lot of the answers pointed to games that are extremely high on the "cheap" scale... I mean yes cheap games are difficult, but yeah it does feel a bit artificial on the difficulty scale.

    Which is also precisely why I didn't think of most platformers as among the hardest games. Like for example the original IWBTG; is it difficult? Sure it is, but a large part of it comes from the game being cheap AF... Someone with good platforming skills can clear every section with a few tries. And the higher difficulties just reduce the number of checkpoints, not actually making the game fundamentally more difficult... I mean there are genuinely difficult platformers but there are objectively more difficult games out there

    so many kinds of difficulty

    I'm actually surprised almost no one mentioned any type of PvP games or games that are primarily reliant on competing against other humans... they go insanely hard, but like how much of Street Fighter's difficulty is you being better than the other person vs just "know how the game works"?

    If you want a game that not many people could beat

    My favourite genre of games almost universally feature levels that probably fewer than 100 people across the world could beat (not counting customs), so... yeah.

  • What is the hardest video game(s) in your opinion, why, and what other games are you comparing against to make this conclusion?
  • Me infodumping about way too much of my thoughts on this topic, possibly bad takes, probably will influence your answer if you haven't typed in anything

    Okay thanks everyone so much! I... wasn't sure what I was expecting to see in the replies, but I definitely had some other games in mind. I was thinking more along the lines of rhythm games (yes IIDX/SDVX I'm looking at you, no I still can't consistently clear lvl17 on SDVX), since most rhythm game feature levels that are just downright humanly impossible... but I assume the JP-based rhythm games are way too niche for most people, and Guitar Hero/Just Dance aren't too difficult in the grand scheme of things

    I guess it makes sense that for many people the most difficult game would be some bizarrely difficult game from the 80s/90s since... I thought the rationale for making a video game challenging is to make it more replayable & create the feel of having more "content"? Games back then literally don't have the technical ability to create a 40+ hrs unique gameplay, so I guess until roguelikes/roguelites became popular it is a good strategy to just make the game really hard (which also coincides with arcades' need to make more money from ppl failing more). Which I guess makes From Soft games quite interesting since they are challenging despite having no lack of gameplay elements in the games themselves

    And speaking of roguelikes/roguelites, I guess if people were to base the difficulty of a game on "how many people could win a run", "how long does it take to git gud", or "how consistently can a reasonably experienced player beat a run", roguelikes/roguelites would top the charts on most difficulty rankings... which I find kind of funny

    I also have a personal hypothesis that for any action-based games, people find games with more "abstraction", i.e. the control scheme is more unintuitive or far-removed from the player, difficult. For example, a 90s platformer would feature you pushing buttons on a controller, which then feeds into your screen character moving while being influenced by game physics, which is an absurdly high amount of abstraction... whereas a game like Fruit Ninja has close to zero abstractions (you literally just swipe the fruit) and would probably be considered quite easy by most. Obviously doesn't apply to non-action based games but I think they are the minority among all video games

    But honestly, I know I'm asking for difficult games here, but I find even just the 1985 Super Mario Bros quite challenging (mostly because of the jank physics engine but more about that another time)... games from that era truly are something else. And this is speaking from someone who had 100%ed or otherwise fully cleared many popular roguelike/roguelites so...

    Anyway I think the short conclusion I had is I should play a few retro games that I haven't had a chance to try yet. Oh and traditional bullet-hells. Just for shits and giggles... thanks!

  • Youtube has fully blocked Invidious
  • I guess I forgot to take that into consideration... I'm not worried about Google banning my IP since I essentially don't use any Google services at all and my home IP is hidden behind a wireguard tunnel, but yes that is a valid concern

    But I mean someone can just spin it up on their home network so... No way 192.168.0.1:3000 can get someone into trouble right

  • What is the hardest video game(s) in your opinion, why, and what other games are you comparing against to make this conclusion?
  • I've really only played Touhou in middle/high school... Imperishable Night was actually a really formative game for me, loved the OST and played quite a bit out of it. Fairly sure I've cleared this particular one on Easy, might have made to Stage 5/6 on Normal... Definitely didn't clear Scarlet Devil on Normal because my motor skills were terrible back then

    I should be able to clear Normal/Hard now that I'm older and more skilled. If I have the patience/time that is...

    Edit: apparently I forgot how to do math and got the game release numbers wrong

  • What is the hardest video game(s) in your opinion, why, and what other games are you comparing against to make this conclusion?

    Forgot what made me think about this topic but I've been considering this for a week or two... Curious what you all think.

    When I mean "hardest" "video game", I mean whatever game that you find objectively more difficult than all other ones on the market, as long as it's a video game. I guess exposure to different genres/types of games can influence the answer to this question a lot so... Hence I was curious about your rationale.

    I have a pretty solid answer & rationale but I guess I shouldn't share that in the main post to bias results...

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    where did you know about lemmy and why did you start using it
  • Don't remember the exact date now but I believe I learned about Lemmy either slightly before or during the first wave of Twitter/Mastodon migration... I was trying to find Reddit alternatives, and quickly realized that the only option is a thing that is run by Tankies where the most popular posts only gathered fewer than 100 upvotes each

    ... anyway the statement did not age well. I've been lurking on Lemmy for the past year but haven't really registered an account so

  • Youtube has fully blocked Invidious
  • The elites don't want you to know but "[y]ou may be able to get Invidious working on residential IP addresses (like at home)"

    Following their guide gives a local Invidious client, don't forget to 1) copy their production compose file instead of using the one on git and 2) change "hmac_key"... from my experience setting up cron (crontab -e) to restart the docker container once per day keeps the Invidious docker healthy


    Edit: here are some alternatives for popular Google services. Not in anyway related to the above (smirk

    • Google itself: SearXNG (try searx.be first), one of the easiest services to self-host
    • Gmail/calendar: a lot of people seem to swear by one of Proton Mail, Tutanota or Mailbox.org. Self-hosting is possible but challenging
    • Google Drive: You mean Nextcloud?
    • Google maps: Organic Maps is actually getting pretty good now
    • Google Chrome: at the very least there is Chromium... obviously there is Firefox and Firefox forks (such as Librewolf), as well as other smaller browsers
    • Google Play: F-Droid hosts a lot of FOSS stuff, and there are alternative ways to access Play (such as Aurora Store)
    • Android: a bit more difficult... but there is LineageOS, GrapheneOS, and similar stuff
  • What's a handy terminal command you use often?
  • Oh god I also do this... See the comment below, I ran history|cut -d " " -f 5|sort|uniq -c|sort -nr|less on my personal laptop, my third most commonly used command (behind ls and cd) is just typing in nothing...

  • TIL the name of computer "bugs" stuck around because a moth got stuck in a computer component in 1947
    americanhistory.si.edu Log Book With Computer Bug

    American engineers have been calling small flaws in machines "bugs" for over a century. Thomas Edison talked about bugs in electrical circuits in the 1870s.

    Log Book With Computer Bug

    But how did this name originally come into place in engineering??

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    InitialsDiceBearhttps://github.com/dicebear/dicebearhttps://creativecommons.org/publicdomain/zero/1.0/„Initials” (https://github.com/dicebear/dicebear) by „DiceBear”, licensed under „CC0 1.0” (https://creativecommons.org/publicdomain/zero/1.0/)ZL
    zlatiah @lemmy.world

    Ask me about:

    • Science (biology, computation, statistics)
    • Gaming (rhythm, rogue-like/lite, other generic 1-player games)
    • Autism & related (I have diagnosis)
    • Bad takes on philosophy
    • Bad takes on US political systems & more US stuff

    I'm not knowledgeable about most other things

    Posts 4
    Comments 15