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This is https://en.m.wikipedia.org/wiki/Takiyasha_the_Witch_and_the_Skeleton_Spectre for anyone interested.
And you can see it referenced in absolutely every anime that has an excuse to have a giant skeleton. Hell there is a show airing currently that references it in the official promo poster or whatever it's called. Once you notice it you can never stop seeing it.
The skeleton represents mass sickness and starvation.
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