Incredibly dumb of AMD to think that game engine hooking dlls wouldn't cause problems with anti cheat software. You can barely even inject OSD info from afterburner/RTSS anymore. I'd be shocked if this didn't impact other games like valorant/fortnite.
Anticheat needs to be sort of zealous to even matter. If you're gearing yourself towards gaming and then messing specifically with the engine in a multiplayer game, in ways that are notorious for being used for cheating... then it's kind of on you.
Don't get me wrong, some anticheat is quite invasive, but still. Necessary evil, fixture of the gaming ecosystem - AMD should've known better.
The anti cheat is doing its job: making sure that nothing sketchy is hooking into the game code or dependent libraries.
It's AMD that should have realised this would be a problem. They know how games are made. They know this stuff exists. They of all people should have seen this coming a country mile away.
Most anti cheats cause problems with everything, the system is 20 years old as you said, it needs to be reworked. Like some users get banned just for playing on Linux...
Anti-cheat on the client should be an anti-pattern. Devs continue to make the mistake of imagining you can control the code running on someone else's device and waste their efforts there instead of working more on the server (preventative) or analysis (punitive) side.