According to posts on online forums, ads have made their way into real-time gameplay in Assassin's Creed Odyssey. One gamer who reported the problem was Redditor triddel24,...
Hell, I'd be fine for in-game adverts in sensible and relatively unintrusive spots (like a Spiderman 2 ad on a times square billboard in Spiderman 1/Miles Morales). But that won't happen.
I used to advise some of the largest companies on in-game advertising and this was exactly what I said over and over.
Fit the in-game world and context and have them placed in the world environments where they feel like part of the world to players.
But that's a lot of extra work, so I was routinely ignored (even though they were bringing me in to advise them).
We'll probably see more of this now that generative AI is a thing, but it's still going to predominantly be stupid stuff like "let's put our image asset into a UI popup while people are playing the game" or "let's replace the boot screen with a video ad that can't be skipped."