What possible, fundamental, misunderstanding of the nature of the universe could make current academics look like flat earthers?
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That evolution is purely randomness + fitness landscape rather than that DNA guides the process at least somewhat. Don’t burn me alive guys
I don’t understand your point but it seems interesting. Could you rephrase?
The current paradigm assumes a uniform probability of mutation across all genes. But maybe there are mechanisms that say “keep this part of the genome under tighter control” and “make this other part of the genome more susceptible to mutation.”
Oh we already know this. There are parts of the genome that, if even slightly changed, cause terrible, terrible things.
Mutations can happen anywhere, but serious mutations (that may affect the basic things a cell needs to do in order to exist) result in cell death and therefore don’t manifest in the population — the population continues on as though the mutation had never existed.
In this way, natural selection conserves some parts of the genome while less essential parts can vary more freely without being deleterious to the organism.
For example, most non-bacteria (including all plants, animals, fungi, protists) have special proteins called histones. Histones are used to package the DNA together and wrap it all up. Cells can’t function at all without a these proteins, and the most important histone proteins evolve so slowly that they’re almost identical between a human and a pea. (Humans and peas shared a common ancestor over half a billion years ago.)
ETA: My molecular biology knowledge is rusty, but IIRC the way DNA is packaged and unpackaged can also reduce or increase the risk of DNA being exposed to potential mutagens. So if it’s wrapped up, it’s harder to access and tamper with
I would expect randomness to play a larger roll than fitness.
In the short term (single digit generations) that's probably true, but I don't see how it could be on longer scales. If the random mutations decrease fitness, they won't be passed on at some point, since there is less reproduction. If they increase fitness, they will be passed on to more individuals.
What OP said is Motoo Kimura's Neutral Theory of evolution. There's a lot of evidence supporting it. The vast majority of mutations have a negligible effect on fitness. So it is very possible that something may evolve purely by chance.