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Canonically? Yes! A giant bat demon named Barbatos that creates twisted versions of Batman (including batman) to torture Bruce Q Wayne
There's also Dr. Gotham, who was a evil sorcerer buried under Gotham for centuries whos evil also apparently poisoned a fair bit of the area.
There's also anywhere between 1 to 3 (Possibly more) Lazarus pits under Gotham, and arguably the chemicals from them have been leeching into the water supply. What do the Lazarus pit chemicals do? Make you resilient to damage and also crazy. What do a significant amount of Bat villains have in common? Injuries/mutations that would kill a normal person, and being off kilter.
Then we have the Asylum which is possibly haunted and has held a portal to Hell at least at one point.
Lots of stuff going on in Gotham.
I am here to doubt the validity of Dr. Gotham's degree and licensure.
Back in the 1800s the qualifications for saying you were a doctor were comically easy to acquire. I don't think any academic dishonesty happened here. Just a product of the time
Your excellent summary has me imagining the day to day work of the staff at the Association for Gotham Tourism.
That's gotta be weird.
If I was the tourism board I'd be like "can we build an ad campaign around doing crime? Come to Gotham, shoplift, and get beat up by the one and only original Batman! A story you'll remember forever!" It's probably safer than bungee jumping, since those guys can't guarantee you won't be killed, but Batman will.
I mean Batman won't kill you, but he'll break your spine in half.