The Great Filter is the idea that, in the development of life from the earliest stages of abiogenesis to reaching the highest levels of development on the Kardashev scale, there is a barrier to development that makes detectable extraterrestrial life exceedingly rare. The Great Filter is one possible resolution of the Fermi paradox.
The Fermi paradox is the discrepancy between the lack of conclusive evidence of advanced extraterrestrial life and the apparently high likelihood of its existence. As a 2015 article put it, "If life is so easy, someone from somewhere must have come calling by now."
Personally I think it's photosynthesis. Life itself developed and spread but photosynthesis started an inevitable chain of ever-greater and more-efficient life. I think a random chain of mutations that turns carbon-based proto-life into something that can harvest light energy is wildly unlikely, even after the wildly unlikely event of life beginning in the first place.
An alternative is we are among the first. Third generation stars are the ones that have planets with enough heavy elements to allow for complex chemistry. Sol (our star) is thought to be among the first batch of third generation stars in our gallexy.
Light speed does seem to be the upper speed limit for the universe. Talking that into account we probably haven't had a chance to see other early life as it would likely be spread pretty thin right now.
This is my favorite, mainly because it's been well argued by some respectable scientists.
Another is that we're in a simulation, and aliens aren't part of it. There are also some very good statistics pointing to the simulation theory, from just sheer scale.