The Great Filter is the idea that, in the development of life from the earliest stages of abiogenesis to reaching the highest levels of development on the Kardashev scale, there is a barrier to development that makes detectable extraterrestrial life exceedingly rare. The Great Filter is one possible resolution of the Fermi paradox.
The Fermi paradox is the discrepancy between the lack of conclusive evidence of advanced extraterrestrial life and the apparently high likelihood of its existence. As a 2015 article put it, "If life is so easy, someone from somewhere must have come calling by now."
Personally I think it's photosynthesis. Life itself developed and spread but photosynthesis started an inevitable chain of ever-greater and more-efficient life. I think a random chain of mutations that turns carbon-based proto-life into something that can harvest light energy is wildly unlikely, even after the wildly unlikely event of life beginning in the first place.
Hard to determine with what we know. We haven't met any other intelligent species which suggests we've passed the filter. Yet, making that conclusion before knowing there are no others to meet is too presumptuous. But, if I were to guess, I'd think the filter is adaptability.
We're superior to animals for being able to use tools, live in radically different climates, and shape every spot on earth into a livable climate. Even on Mars, the moon, and space. How else would a species venture through space if they can't adapt?
That might be too general a concept for the question though.
We haven't progressed far enough to be detectable by intelligent life in other star systems, even the closest ones. The filter can easily be in front of us. It could just simply be that interstellar space travel is too infeasible, so intelligent species never reach beyond their home system.
Yet we haven't even found other planets with complex dumb life, much less ones with intelligence, communicative life. Nothing like what we have on Earth, not even close. Either space is too big or we're past the filter.
We are nowhere near advanced enough to say that life, complex or intelligent, doesn't exist anywhere near us. There is no reason to believe an intelligent spacefaring race would make themselves so obviously detectable that us stupid primates could see them. And for non-intelligent life, we've been able to confirm mere thousands of planets. We have a very long way to go before we can start talking about the meaningfulness of a lack of life signatures in the atmosphere.