With a budget of $120 million, Francis Ford Coppola's "Megalopolis" grossed only $4 million on its opening weekend, making it one of the worst box office openings for a $100M+ movie to date.
Factoring in marketing costs and the theaters taking their cut of the profits, Megalopolis would need to make at least $300 million to break even. I think it's safe to say that's not happening.
It would have been THE worst opening for a $100 million movie ever, had it not been for Pluto Nash's horriffic opening 22 years ago.