What's the biggest plot hole in real life?

Since the latest season hasn't concluded yet, let's only look at plot holes from 1990 and before.

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What did drugs ever do to start a war???
- Well, the British were able to use drugs to start a war on China once. All in the name of cheap tea.
  
  Some would say the fentanyl problem right now is payback for the opium thing
- Because Dewey Cox never once paid for drugs.

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