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Probably already said here, but it's going to just come down to your end goal to know what distro fits what you're looking for.
I am personally a huge fan of Gentoo, another distro that's all about "from the ground up" approach. It's actually where I started with Linux and is how I became as proficient in it as I am today. In fact my internal server that does everything is running Gentoo as it's OS... Has never had any problems in the last decade that would require a reinstall or anything crazy like that.
But even as much love as I have for Gentoo, I have Linux Mint installed on my laptop. Why? Because it's just more convenient when I need my full focus on the 10 other personal projects I'm working on... Also amazing on the gaming front. Doesn't have nearly as much bloat as some other Ubuntu-based distros on first install, has a huge community support, and is just great all around to have.