Many women who work at McMurdo Station, the main United States research base in Antarctica, say the isolated environment and macho culture have allowed sexual harassment and assault to flourish.
The National Science Foundation, the federal agency that oversees the U.S. Antarctic Program, published a report in 2022 in which 59% of women said they’d experienced harassment or assault while on the ice, and 72% of women said such behavior was a problem in Antarctica.
But the problem goes beyond the harassment, The Associated Press found. In reviewing court records and internal communications, and in interviews with more than a dozen current and former employees, the AP uncovered a pattern of women who said their claims of harassment or assault were minimized by their employers, often leading to them or others being put in further danger.
TL;DR female astronauts have, according to the study:
a higher risk of cancer (a 45-year-old man has a 344-day limit in space to be safe versus a 187-day limit for a 45-year-old woman)
more orthostatic intolerance
more UTIs (which makes sense as women on earth are also more likely to have UTIs)
less vision impairment compared to male astronauts (no clinically significant cases of VIIP syndrome)
less hearing problems (men show a more rapid decline in the left ear and in general like on Earth)
Keep in mind that this data is not the best because only around 20% of people that had been on the ISS at the time were women and because male astronauts are more likely to come from a military background.
Hearing sensitivity, when measured at most frequencies, declines much more rapidly in male astronauts than it does in female astronauts. These LSAH derived data represent a wide age range of subjects (i.e., four decades) and show a more rapid decline in hearing in the left ear, for men only. Within the general population, hearing also declines more rapidly in men than in women, due in part to environmental factors or occupational exposure (e.g., construction or factory work). No evidence suggests that the sex-based hearing differences in the astronaut population are related to microgravity exposure, and the small sample size of female astronauts precludes making any definitive conclusions.
How much exactly are those 'fewer' negative effects. Micro Gravity is but a tiny obstacle to the forces we need to overcome in terms of long distance space travel. I'd be more concerned with cosmic rays, waves, and radiation just sweeping by and lethal dosing everyone without warning.