New Alzheimer's Nasal Spray Clears Toxic Tangles in Human Neurons And Mice
Twisted and tangled proteins are found in the brains of many of those who die with Alzheimer's disease.
Important bit:
In experiments on postmortem human brain tissue donated from patients with Alzheimer's disease, dementia with Lewy bodies, and Pick's disease (a form of frontotemporal dementia), the novel antibody medicine not only cleared away tau tangles but also stopped the release of 'tau seeds', which travel via connected neurons to tangle up proteins in other parts of the brain.
Many open questions remain, including whether this treatment delivered intranasally in humans will allow penetration of the antibody in effective doses throughout our much larger brains and whether there are any potentially dangerous side effects like inflammation, which is a concern in all of the amyloid-directed immunotherapy trials," write Meftah, Durrant, and Spires-Jones.
Courtesy of UTMB!!
So. Take it preemptively as well?
We're on track to have the smartest, healthiest, elderly mice this century! Here's to hoping some of these treatments are applicable to humans as well.
