I liked Andromeda the game more than most but I really didn't like Andromeda the galaxy as a setting. I'd prefer to go back to the milky way with the species from the original games. Maybe set in the future after a major political upheaval or something.
Yea I'm not married to the Andromeda storyline either.
I personally think a mass effect prequel game about the first contact war (or whatever the war was between the humans and the Turians) would be the most interesting.
the only issue I have with that is it would be a step backwards in alien varieties, especially in your party. For me one of the best parts of ME was the feeling of being part of a galactic community, walking around the citadel with a bunch of different aliens, etc.