Right now I just want the bug-free stability, and the well developed communities for every niche subject imaginable, but I'm sure those will come in time.
I'm using Jerboa and the only thing I miss is the "view context" button on my notification messages, and the option to "view parent comment" when viewing an individual comment. Searching and linking between instances needs to become more seemless too, and maybe better integration with things like Mastadon, although I don't use it personally.
I also think up/downvote history being public is a terrible idea and would like to be able to disable that in an account's privacy settings, idk if that will ever be possible.
(Edit) Also the ability to migrate your account and posting history to a different instance, so that users can easily vote with their feet if their home instance gets defererated or makes an unpopular decision. Again idk if that will ever be possible or not