No connoisseur here either, but I am in dire need of a new one for work, as my current one is falling apart. I'm keeping my eyes open, in case I find one that matches these specs:
Durable as hell
1x compartment that can fit two 15" laptops. Chargers can go in a different compartment.
1x general purpose compartment for misc cables, SFP modules, connectors and other work related junk
1x compartment for a change of clothes
2x easy access pockets for things I might need to reach while on the go
2x zippable easy access compartment for things such as keys, battery bank, etc
must be small enough to count as carry-on with most airlines
I'm leaning towards getting one of those pilot backpack, as they're built for people who are on the go.
The reason I'm an Osprey fan is because of the lifetime warranty for any reason, which impressively I've never had to use. And I abuse my gear outdoors.
But I'd imagine if you are doing tech carrying over everything else, you want something more specialized/padded. I try to find lighter gear.
When I have loads or large hardware I usually check in a pelicase or two. The backpack is mostly for short-term in-transit stuff plus bits and pieces I usually need for short stays.
Osprey looks nice - I'll see if they have something that suits my needs