Industry body Entertainment Software Association (ESA), which ran E3, confirmed to the BBC that the event will not go ahead in the future.
It started as a trade show in LA in 1995, just after the launch of the PlayStation and the year before the Nintendo 64 was released.
Its 2005 event unveiled the Xbox 360, PlayStation 3 and a prototype of the Nintendo Wii.
But as big players such as Nintendo, Ubisoft and Sony began launching new games at their own in-house events, E3 became less relevant and struggled to attract the exclusive announcements it once had.
He added that gaming companies running their own events "are a cheaper, flexible, and more effective way to reach an audience and control the release of news".
"In its heyday E3 was viewed as an unmissable event and was hugely important for pre-launch buzz and the reveal of upcoming games and products.
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