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I was planning to sign up at BeeHaw because it seems pretty active and with high quality discussions. When I heard that it had defederated from Lemmy.ml and Lemmy.world I decided not to sign up to any of those three as I would rather have access to all of them (though I can understand why BeeHaw defederated). So I just went with VLemmy.net as it was one of the recommended ones (on join-lemmy.org and the Awesome-Lemmy-Instances GitHub) and seems to be very broadly federated.
I don't think it matters too much, though I think if you were signed up on the same instances as all your favourite communities it would be a bit more convenient.
What does it mean they were defederated? How does that impact lemmy.World etc
This means beehaw will not see any content from the servers they defederated from, effectively preventing trolls and toxic users from harassing people in beehaw.