I don't know, if LoL uses it, but there's some pretty ridiculous infrastructure in place for DRM, where programs can detect that your entire hardware stack (CPU → GPU → cable → Monitor) hasn't been tampered with: https://en.wikipedia.org/wiki/High-bandwidth_Digital_Content_Protection
They still can't detect when you're filming your monitor, but pretty much everything else...
Depending on the game, this could open you up to a perma-ban (if found out). Which I think most multiplayer games take a hardline stance against circumventing their rules.
And that's actually an argument against buying this monitor, as long as you want to play any games with it. They have reason to ban you just for using this monitor. So in the end you have the choice between one monitor that could get you banned and all the others that don't. I know which one I wouldn't choose.
Yup. The fastest return of my life was when I found out my mouse was banned from the game I literally bought a few minutes earlier. Of course it was Rust. Just because I have a mouse with macros and scripts doesn't mean I'm using them (I really don't lol).