Pretty sure Minecraft was the most profitable game of all time.
And you can be that reductive for pretty much all games. Run right and jump on mushrooms. Watch shapes rotate and fall. Punch cubes. Three of the other most profitable games of all time.
Minecraft is the highest selling game (beating out GTA V by 110 million units sold source), but it's not the most profitable. GTA does have it beat there ($9.9 billion vs $3.3 billion). Though CoD has them both beat at $31 billion (source).
That's true (to be even more precise, the GTA metric is also for the franchise...which GTAV makes up $8.5 billion of >.>). How about Candy Crush at $20 billion?