Now I'm no world leader who has just been accused of genocide by a good chunk of the entire world, so maybe I'm out of my depth on this one, but personally, if it were me, I would start out with denying the accusations, followed by explaining exactly how what my country is doing differs from genocide. What I would definitely not do is simply try to exert my severe lack of power over other world leaders who are asking extremely reasonable questions and drawing a straight line from those to conclusions of genocide.
Based on his reported actions, I believe we have no other choice than to conclude that Netanyahu is extremely suicidal and is hoping for it all to be over soon.