Excess protein consumption in western societies can lead to cardiovascular risks
Excess protein consumption in western societies can lead to cardiovascular risks
www.nature.com Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk - Nature Metabolism
Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious macrophage mTORC1 signalling and promote cardiovascular disease.
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So I've been reading through this study and comparing it to modern health advice. For the most part, the 22% of energy threshold seems to be above 1.2-1.6 grams of protein per kg of body weight (for active individuals).
The functional advice is: following the guidelines from the FDA will keep you out of the risks outlined in the study.
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