I generally do not run with them however when I was training for and running longer distances I would tend to wear them on those longer runs (15+ miles) mental or not , not sure but I felt like they help with fatigue.
Also in colder weather I've worn them to just keep my calves warmer / seemingly help with early tightness.
For me personally they're not like night and day difference but they do have use case that seem to help.
I've run ultras in the past and i honestly found wearing then down around my ankles and only pulling them up for brief recovery walks or after any race felt way better to me.
To clarify, i was talking about calf sleeves. I've never noticed a diff between shorts vs leggings.
Mine were as well. I used to play soccer so i didn't really have the typical runners calves so they were tight as hell on me which is probably why i never enjoyed running in them for longer distances.