In Eternal Darkness: Sanity's Requiem, we play as multiple different protagonist throughout history as they fight against the Ancient (that the player chose as the antagonist at the early stages of the game).

The list includes:

1. 26 BC: Pious Augustus, a Roman Centurion
2. 565 AD: Karim, a Persian swordsman
3. 1150 AD: Ellia, a court dancer
4. 1485 AD: Paul Luther, a Franciscan monk
5. 1760 AD: Dr. Maximillian RoivasHis chapter takes place in 1760 AD
6. 2000 AD: Alex, an university student