In the year 2019 AD, a mysterious flash suddenly petrifies nearly all human life. The human race frozen in stone for 3,700 years.

The story follows Senku Ishigami, also known as Dr Stone, use his scientific intellect to rebuild civilization and uncover the truth behind the petrification. Throughout his journey, he re-invented various modern items, such as explosives, tank, radio intercom, cameras and even Cola.