Made in Abyss follows a young Delver girl by the name of Riko, as she delves deeper into The Abyss, a gaping chasm stretching down into the depths of the earth, filled with mysterious creatures and relics from a time long past.

As they delve deeper into the Abyss, Delvers experiences the Curse of the Abyss, a series of increasingly severe ailments.

Here are a list of some known ailments at various levels:

• 1st Layer: nausea,
• 2nd Layer: headache and numbness of extremities
• 3rd Layer: vertigo and hallucinations
• 4th Layer: intense pain all over the body and bleeding from all orifices
• 5th Layer: loss of all senses and self-harm