I do and have for most of my life. I lived on an island where my SO and I were the only permanent residents for 8 years.
I have lived in the suburbs of a couple of large towns/small cities for some years too - and in the centre of an all-but-city and although there is some convenience in those, I'd choose rural any day. The peace, proximity to nature and the ease of getting out for enjoyable walks beats convenience every time for me.