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So I started DIY a few months ago using estradiol gel for monotherapy (2.5g 0.06% gel applied scrotally twice a day for a total of 3 mg estradiol / day). I saw plenty of expected effects, including nipple sensitivity and no more spontaneous erections (after a month or so even direct stimulation was starting to get less effective). No blood tests, but I conclude estrogen levels are probably OK-ish and testosterone must be somewhat suppressed.

This month, I get on prescription injections instead at last. The standard course here is monotherapy, 10 or 20 mg estradiol valerate (Progynon) as an IM depot injection every two weeks. Different schedules, progestogens, anti-androgens etc are available but I'm probably going to have to advocate for that myself if necessary. First injection, 10mg; I stopped using gel that day. All seems OK, but a few days in, I start getting erections at night again. Weird, but I assume it could be an occasional thing. By day six, they're happening every night, s