Until the instance you choose to set up on ends up in a feud with any, or all of those instances.

The whole fediverse experiment is going to end up with a number of small, highly segregated communities, and even more political polarization. I guess if you want to live in an echo chamber, a federated environment is the best way to go about it.

And this is why the fediverse will never work out - if I gamble wrong and set up shop on an instance that gets in a pissing match with other ones, I either have to make an account elsewhere (and then have to do it again later the next time two instances defederate each other) or live with only seeing some of my subscribed content.