Yes it does matter, they use better parts that are rated for better temperature scaling and vibrations and have features that allow the drives to be more reliable and accessible.

If you are just storing data that is going to be shelfed .. maybe not so much, just buy a drive that has a high reliability rating, put you stuff on there, unplug it and move on with life, but if the data is being used and writen and read on a regular basis, having NAS rated drives like IronWolf or Exos does matter.

of course it matters. wtf ? NAS drive will typically have additional features that are useful to have in a NAS like anti-vibration, head parking disabled, low speed idles, etc....

Exos are enterprise .. NAS drives....