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FDA faces backlash over approval of genetic test for opioid addiction risk
  • Total error rate is about 2/5? That's barely better than a coin flip.

    "Oh yes, I just got tested for my potential to become an opioid addict. Give me a second to flip a coin: heads I read the report, tails I toss it in the recycle bin."

  • Google Street View reveals how built environment correlates with risk of cardiovascular disease
  • I think you're on the right track, but have identified the wrong place to insert a law. It shouldn't be illegal to do this work. It should be illegal for insurance companies to abuse it through eligibility, premiums, and claims restrictions.

  • Don’t use unsterilized tap water to rinse your sinuses. It may carry brain-eating amoebas
  • Sorry for the tangent. This conversation kicked up more nostalgia than I expected.

    No problem.

    Heh! You had blasting caps, we had carbide (my grandfather was still running an acetylene generator in his welding/machine/mechanic shop).

  • Don’t use unsterilized tap water to rinse your sinuses. It may carry brain-eating amoebas
  • I'm more concerned about e coli levels than amoeba. But Lord only knows what gets into the South Saskatchewan River system and what grows vigorously once the water slows down in Lake Diefenbaker.

    At least I've stopped swimming in the runoff sloughs in cattle pastures. (Kids are all kinds of stupid!)

  • Don’t use unsterilized tap water to rinse your sinuses. It may carry brain-eating amoebas
  • Hah. I've been swimming in freshwater lakes, rivers, and reservoirs for about 65 years. Ain't nothin' takin' me down.

    Also a former water treatment plant operator, so I should probably not be quite so complacent. :)

  • Study: Dark matter does not exist and the universe is 27 billion years old
  • I think you could consider all of physics or even all of science to be made up of placeholders meant to keep things moving until a better explanation comes along.

    I agree. I would add that intuition, common sense, and ideologies are also just placeholders in our journey to a better world.

  • The superior citation method
  • Thank you!

    I appreciate the comparison and analysis. I'll keep it in my "maybe I'll tackle it someday" list, but I've mostly moved away from writing that is hostile to the reader.

    I don't have a problem with complex concepts, even when they ultimately go over my head. I don't even have a problem with stylistic weirdness in service of the message. I draw the line at writers who treat me like an imbecile, whether directly or through their own sense of superiority.

    Actually, the long "Giving Tree" excerpt in one of the reviews reflects my own views. If that means we might already share opinions, then I for sure don't need to suffer abuse along the way. 😀

    An obvious problem with my attitude is that I then shut myself off from discussing the merits of a work.

  • The superior citation method
  • At that point, I think pulling it out to an appendix is the right thing to do. Whenever I find a book with appendices, I do one of two things.

    1. If an appendix looks like "prerequisite" material, I read it first.

    2. If it looks like "further reading" or "deeper dive" material, I note where it's referenced in the main text and return to it later.

    The main reason I prefer footnotes to end notes is the separation of concerns. When a book has end notes, they are usually mixed with citations. I don't mind managing 2 bookmarks or the eReader linking back and forth, but I really dislike following the reference to find that it just points at a whole other book.

  • The superior citation method
  • Structurally, the most challenging book I've ever read was "The Message of THE QUR ĀN" by Muhammad Asad.

    Start with the fact that the QUR ĀN itself is extremely non-linear. So much so that I think that this alone requires a great deal of study to address.

    The text is 2 columns, the original Arabic adjacent to his English translation. There are copious and often long footnotes. The footnotes cross reference other footnotes, sometimes in chains. I read only the English.

    I had to read it 4 times. Once just ignoring footnotes. Again, this time including just first-level footnotes. Again, following footnote chains back to their sources in the text. Finally, to reread just the text after pretending that I had everything figured out.

    It took me a year to get through it to my satisfaction, although it was not the only reading, or even major project.

  • hmmmm
  • Only if those people can also be infinitely packed into the distance the leading truck (the set of wheels) manages to travel.

    Which, I guess is fair play in a thought experiment involving different sizes of infinities. :)

  • hmmmm
  • Thanks. This is the first time I've seen a jokey enough presentation to feel comfortable in treating it as a hypothetical reality rather than a moral/ethical exercise.

  • hmmmm
  • Yes, or come to a halt. You'd be surprised at how little it takes to reduce the already low friction to nothing. A bit of blood and a bit of resistance will bring it to a halt pretty quickly.

  • hmmmm
  • It's always better to gain a full understanding of the system when trying to make important decisions.

    The trolley has two sets of wheels, leading and trailing, both of which must remain on the same set of tracks.

    The switch is designed to enable the trolley to change course, moving from one set of tracks to the other.

    Throwing the switch after the leading set has passed, but before the trailing set has reached the switch points will cause the two sets to attempt travel on separate tracks. The trolley will derail, rapidly coming to a halt. If the trolley is moving slowly enough to permit this action, nobody dies.

    Source: former brakeman (one of the people responsible for throwing switches), section hand (one of the people responsible for installing switches), and railroad welder (one of the people responsible for field repairs of switches).

  • Parkinson's Disease Is Predominantly an Environmental Disease - PubMed
  • Interesting. One of the chemicals they reference is tetrachloroethylene. According to this Wikipedia article:

    Perhaps the greatest use of TCE is as a degreaser for metal parts. It has been widely used in degreasing and cleaning since the 1920s because of its low cost, low flammability, low toxicity and high effectivity as a solvent. The demand for TCE as a degreaser began to decline in the 1950s in favor of the less toxic 1,1,1-trichloroethane. However, 1,1,1-trichloroethane production has been phased out in most of the world under the terms of the Montreal Protocol, and as a result, trichloroethylene has experienced some resurgence in use as a degreaser.[17]

    My grandfather had Parkinson's. I would imagine that he had plenty of exposure in his work as a mechanic from about 1925 on.

  • DNA testing: What happens if your genetic data is hacked?
  • Isn't it sad that certain negative outcomes can be easily predicted by anyone bothering to think things through, yet no effort ever seems to go to mitigation, only spin and crocodile tears after the fact.

  • InitialsDiceBearhttps://github.com/dicebear/dicebearhttps://creativecommons.org/publicdomain/zero/1.0/„Initials” (https://github.com/dicebear/dicebear) by „DiceBear”, licensed under „CC0 1.0” (https://creativecommons.org/publicdomain/zero/1.0/)JA
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