One City that doesn't get mentioned much here is Tübingen(~70k) in the south. Its pretty much as liberal as Berlin, probably the most accepting city under 500k population in Germany. It is ridiculously beautiful with a huge old town, and as someone who is queer and spends time there often, it feels very safe. The queer community is huge because there is tons of students. It has amazing City Planning / Cycling Infrastructure / Public Transport, and the surrounding nature is beautiful as well.

Its also pretty easy to get it setup to a semi-customized basic look and feel. Use one of the bigger themes, a popular Icon pack and a nice matching wallpaper as well as a little task bar customization and some widgets and youre set, and all this takes less than two hours.