Longevity
- David Sinclair Supplements: A Deep Dive To His Supplement Regimenfoodnourish.net David Sinclair's Supplement Protocol [Updated 2024]
Get the latest insights on David Sinclair's 2024 Supplement Protocol and discover why he's chosen NMN, Resveratrol, and more for optimal longevity.
Exploring the Latest Supplements, Vitamins, and Medications in Sinclair's Longevity Regimen
- [SciShow] Do We Have to Die?
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Maybe, maybe not. More research is needed.
- A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells - Nature Agingwww.nature.com A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells - Nature Aging
Zeng, Shi, Han, Hu, Li, Wei et al. present a metabolic atlas covering 15 hematopoietic cell types from young and aged mice. By screening metabolites that are depleted with age, they identify that uridine treatment can restore function in aged hematopoietic stem cells.
Through metabolic screening, we identified uridine as a potential regulator to rejuvenate aged HSPCs.
- Inhibition of IL-11 signalling extends mammalian healthspan and lifespan - Naturewww.nature.com Inhibition of IL-11 signalling extends mammalian healthspan and lifespan - Nature
IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan.
- A Molecular Reason Why Exercise Fights Senescencewww.lifespan.io A Molecular Reason Why Exercise Fights Senescence
Researchers publishing in Aging have found a molecule linking exercise to the inhibition of cellular senescence, one of the hallmarks of aging. Exercise against senescence We recently […]
Researchers publishing in Aging have found a molecule linking exercise to the inhibition of cellular senescence, one of the hallmarks of aging.
- Encouraging Mitochondrial Maintenance to Fight Senescencewww.lifespan.io Encouraging Mitochondrial Maintenance to Fight Senescence
Researchers have published a method of rescuing cells from damaged mitochondria and cellular senescence, potentially alleviating major aspects of aging. Bad mitochondria must be […]
The researchers investigated whether NAD precusors, including nicotinamide and NR, along with the well-known compound rapamycin could rescue mitophagy, and they found positive results for all of these compounds.
- TERT activation targets DNA methylation and multiple aging hallmarks
TAC promoted tissue rejuvenation, including new neuron formation, and alleviated multiple aging hallmarks in aged mice, revealing the regenerative potential of adult tissues through physiological TERT activation.
- Oral Microbiome Associated with Cognitive Performancewww.lifespan.io Oral Microbiome Associated with Cognitive Performance
An analysis of oral microbes in older adults has indicated an association between microbial diversity and executive function performance [1]. Multiple factors impact cognitive impairment risk Aging is one of the major risk factors for cognitive impairment and dementia, but […]
The authors elaborate on the potential mechanisms underlying the connection between oral microbial dysbiosis and cognitive function impairment.
- Integrative epigenetics and transcriptomics identify aging genes in human bloodwww.biorxiv.org Integrative epigenetics and transcriptomics identify aging genes in human blood
Recent epigenome-wide studies have identified a large number of genomic regions that consistently exhibit changes in their methylation status with aging across diverse populations, but the functional consequences of these changes are largely unknown. On the other hand, transcriptomic changes are mor...
- Estrogen Metabolite Robustly Increases Lifespan in Male Micewww.lifespan.io Winners and Losers in Extending Mouse Lifespan | Lifespan.io
In the newest study by the Interventions Testing Program, 16α-hydroxyestriol and canagliflozin significantly increased lifespan in male mice but were deleterious for females [1]. The golden standard The Interventions Testing Program, now entering its 20th year, is a monumental […]
>16α-hydroxyestriol was the star of this study, producing a 15% increase in median lifespan in male mice. However, it lowered median lifespan in females by 7%. While many drugs affect lifespan sex-specifically, opposing effects are rare; in fact, this is the first case in ITP’s history. Interestingly, we have another example from the same study: canagliflozin, when started at 16 months of age, led to a 14% increase in median lifespan in males and a 6% decline in females. In a previous ITP study, when started at 6 months, canagliflozin increased male lifespan without affecting female lifespan. All other tested drugs did not have a statistically significant effect on lifespan in either sex.
- Alzheimer’s Takes a Financial Toll Long Before Diagnosis, Study Findswww.nytimes.com Alzheimer’s Takes a Financial Toll Long Before Diagnosis, Study Finds
New research shows that people who develop dementia often begin falling behind on bills years earlier.
- Alzheimer's Might Not Actually Be a Brain Disease, Expert Revealswww.sciencealert.com Alzheimer's Might Not Actually Be a Brain Disease, Expert Reveals
The pursuit of a cure for Alzheimer's disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.
- Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging - Microbiomemicrobiomejournal.biomedcentral.com Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging - Microbiome
Background People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and translocation, which may lead to non-AIDS-related aging-associate...
- Humans are living longer than ever no matter where they come fromarstechnica.com Humans are living longer than ever no matter where they come from
Disease outbreaks and human conflicts help dictate regional differences in longevity.
- Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans - Nature Communicationswww.nature.com Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans - Nature Communications
Wang et al. profile age-dependent miRNAomic changes in worm tissues and extracellular vesicles (EVs). They show that ageing controls miRNAs in a tissue-specific manner and their findings further suggest a complex EV-mediated miRNA trafficking network across tissues.
- The fountain of youth is ... a T cell?www.sciencedaily.com The fountain of youth is ... a T cell?
Scientists have found a way to reprogram T cells to fight aging. After using them to eliminate specific cells in mice, the scientists discovered they lived healthier lives and didn't develop aging-associated conditions like obesity and diabetes. Just one dose provided young mice with lifelong benefi...
- A brain-dead man was attached to a gene-edited pig liver for three dayswww.technologyreview.com A brain-dead man was attached to a gene-edited pig liver for three days
Doctors are exploring how to use animal organs but keep them outside people's bodies.
- Third Major Study Finds Evidence that Daily Multivitamin Supplements Improve Memory and Slow Cognitive Aging in Older Adults | Mass General Brighamwww.massgeneralbrigham.org Third Major Study Finds Evidence that Daily Multivitamin Supplements Improve Memory and Slow Cognitive Aging in Older Adults | Mass General Brigham
In a meta-analysis of 5,000 participants, including more than 500 who underwent in-person assessments over two years, multivitamins showed benefits for memory and global cognition. Learn more.
- These fish live beyond 100—and get healthier as they agewww.nationalgeographic.com These fish live beyond 100—and get healthier as they age
Buffalofish have surprisingly long life spans, a new study shows—and live their best lives into their 80s and 90s. What can humans learn from them?
- A universal molecular mechanism driving agingwww.biorxiv.org A universal molecular mechanism driving aging
How cell replication ultimately results in aging and the Hayflick limit are not fully understood. Here we show that clock-like accumulation of DNA G-quadruplexes (G4s) throughout cell replication drives conserved aging mechanisms. G4 stimulates transcription-replication interactions to delay genome ...
- Sirtuin 2 Overexpression Fails to Extend Life in Micewww.fightaging.org Sirtuin 2 Overexpression Fails to Extend Life in Mice
One long-lasting result of the hype engineered over sirtuin 1 overexpression as a possible avenue to modestly slow aging is a continued focus on other sirtuins in the context of aging. Sirtuin 1 overexpression turned out to be entirely unimpressive, a dead end. Sirtuin 6, however, is more interestin...
- Total Meat Intake is Associated with Life Expectancy: A Cross-Sectional Data Analysis of 175 Contemporary Populationswww.ncbi.nlm.nih.gov Total Meat Intake is Associated with Life Expectancy: A Cross-Sectional Data Analysis of 175 Contemporary Populations
The association between a plant-based diet (vegetarianism) and extended life span is increasingly criticised since it may be based on the lack of representative data and insufficient removal of confounders such as lifestyles.We examined the association ...
- Why you should grow and keep big musclestodaypurpose.com Why you should grow and keep big muscles
Life isn’t just about how long we live; it’s about how well we live it. We often hear about increasing our lifespan, but is a longer life worth it if we can’t move and become dependent on others? What’s equally, or even more important, is enhancing our healthspan—the period during which we enjoy a g...
- Could dinosaurs be the reason humans can't live for 200 years?theconversation.com Could dinosaurs be the reason humans can’t live for 200 years?
Our mammal ancestors evolved to compete with dinosaurs but may have lost something in the process.
- The brain undergoes a great "rewiring" after age 40bigthink.com The brain undergoes a great "rewiring" after age 40
In the fifth decade of life, our brain begins a radical "rewiring" that results in networks becoming more integrated and connected.
- Mid-old cells are a potential target for anti-aging interventions in the elderly - Nature Communicationswww.nature.com Mid-old cells are a potential target for anti-aging interventions in the elderly - Nature Communications
In this study, the authors introduce the concept of a unique cellular subtype within the organic stroma, which does not conform to a typical young or senescent but is significantly associated with age-related organic dysfunction among the elderly.
- Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC) - Scientific Reportswww.nature.com Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC) - Scientific Reports
Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or limbs. However, current methods for artificial control of cerebral circulation can abolish pu...
- Neuroscientists engineer a protein that enhances memory to respond to anti-aging drugmedicalxpress.com Neuroscientists engineer a protein that enhances memory to respond to anti-aging drug
Neuroscientists at the Faculty of Medicine and Surgery of the Catholic University, Rome, and the Fondazione Policlinico Universitario Agostino Gemelli IRCCS have genetically modified a molecule, the protein LIMK1, which is normally active in the brain, with a key role in memory. They added a "molecu...
- Time perception and age: Longevity’s influence on ‘mind time’blogs.bcm.edu Time perception and age: Longevity’s influence on ‘mind time’
Dr. Kristin Kostick discusses what might happen to our sense of time if we live radically longer lives.
- Psychiatric Disorders Before and After Dementia Diagnosisjamanetwork.com Psychiatric Disorders Before and After Dementia Diagnosis
This nationwide cohort study conducted in Sweden compares the temporal risk patterns of psychiatric disorders before, at the time of, and after a dementia diagnosis between patients without vs with dementia.
- Celebrating What's Right With Aging: Inside the Minds of Super Agerswww.aarp.org Celebrating What's Right With Aging: Inside the Minds of Super Agers
Some people in their 80s and 90s show shockingly little decline in their brainpower. Scientists are beginning to understand what makes them different and how the rest of us might benefit
- A company uses AI to fight muscle loss and unhealthy agingleaps.org A company uses AI to fight muscle loss and unhealthy aging
There’s a growing need to slow down the aging process. The world’s population is getting older and, according to one estimate, 80 million Americans will be 65 or older by 2040. As we age, the risk of many chronic diseases goes up, from cancer to heart disease to Alzheimer’s. BioAge Labs, a company b...
- Overactive Cell Metabolism Linked to Biological Aging - Neuroscience Newsneurosciencenews.com Overactive Cell Metabolism Linked to Biological Aging - Neuroscience News
Human cells with impaired mitochondria expend more energy. While this hypermetabolism enhances a cell's short-term survival, it also dramatically increases the rate at which the cell ages.
- The Slow Spread of Off-Label Use for Treatments Shown to Target Mechanisms of Agingwww.fightaging.org The Slow Spread of Off-Label Use for Treatments Shown to Target Mechanisms of Aging
A small number of low-cost and generic drugs have extensive human use and safety data, but also a sizable, compelling body of animal study evidence to either (a) suggest a likely modest slowing of aging, e.g. rapamycin, or (b) demonstrate the ability to target a mechanism of aging to reverse age-rel...
- Social connection and mortality in UK Biobank: a prospective cohort analysis - BMC Medicinebmcmedicine.biomedcentral.com Social connection and mortality in UK Biobank: a prospective cohort analysis - BMC Medicine
Background Components of social connection are associated with mortality, but research examining their independent and combined effects in the same dataset is lacking. This study aimed to examine the independent and combined associations between functional and structural components of social connect...
- Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis - Nature Agingwww.nature.com Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis - Nature Aging
Guo et al. demonstrate that oral administration of chiral nanoparticles ameliorates Alzheimer’s disease-associated pathology and cognitive decline in mice via an increase in the gut metabolite, indole-3-acetic acid, potentially a therapeutic target.
- How a dirty litter box could slow you down as you agewww.colorado.edu How a dirty litter box could slow you down as you age
Some people infected with the common, cat-borne parasite Toxoplasma gondii are more likely to be frail as they get older, new research shows.
- Reversal of biological age in multiple rat organs by young porcine plasma fraction - GeroSciencelink.springer.com Reversal of biological age in multiple rat organs by young porcine plasma fraction - GeroScience
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly accurate molecular biomarker of a...